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NAD+ Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair

Evandro Fei Fang, Henok Kassahun,
Deborah L. Croteau,
Mark P. Mattson, Hilde Nilsen,
Vilhelm A. Bohr


Mitochondrial damage and NAD+ depletion are key features in ataxia telangiectasia. Fang et al. show that mitochondrial dysfunction in ATM deficiency is caused by compromised mitophagy due to NAD+ /SIRT1 inhibition. NAD+ replenishment significantly extends lifespan and improves healthspan in both ATM worms and mice through mitophagy and DNA repair.